Samuel O Onoja1 
,
Samuel C Udem2,
Aruh O Anaga2
For correspondence:- Samuel Onoja Email: onoja.samuel@mouau.edu.ng
Accepted: 13 April 2018 Published: 30 September 2018
Citation: Onoja SO, Udem SC, Anaga AO. Hypoglycemic, antidyslipidemic, hepatoprotective and anti-lipid peroxidation activities of hydromethanol leaf extract of Helianthus annuus in alloxan-induced diabetic rats. Trop J Pharm Res 2018; 17(9):1817-1824 doi: 10.4314/tjpr.v17i9.20
© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the hypoglycemic, antidyslipidemic, hepatoprotective and anti-lipid peroxidation effects of hydromethanol leaf extract of Helianthus annuus (HLEHA) in alloxan-induced diabetic rats.
Methods: The extract was administered once daily at 150, 300 and 600 mg/kg for 21 consecutive days. Glibenclamide (GLB) 2 mg/kg was used as a reference drug (positive control) and 5 % Tween-20 solution in water was used as negative control. The fasting blood glucose (FBG) and body weights were measured on days 7, 14 and 21 while glycosylated haemoglobin concentration (HbA1c), serum markers of liver function, lipid profile, antioxidant status, histopathological changes in pancreas and liver were determined 24 h after the last dosing on day 21.
Results: The GLB and HLEHA caused significant (p < 0.05) time-dependent weight gains in the treated rats when compared with 5 % Tween-20 treated rats. The HLEHA and GLB caused significant (p < 0.05) decreases in FBG, HbA1c, malondialdehyde, and lipid profile levels in the treated rats when compared with rats in 5% tween-20 treated group. Alloxan-induced pancreatic and hepatic degeneration were reversed in GLB- and HLEHA-treated rats.
Conclusion: Helianthus annuus demonstrates potent antidiabetic, antioxidant and antidyslipidemic activities in rats.
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